LYRICA (pregabalin) – a gabanergic antiepileptic drug commonly used to treat various neuropathic pain disorders. LYRICA (pregabalin) binds with high affinity to the alpha2-delta site (an auxiliary subunit of voltage-gated calcium channels) in central nervous system tissues. Although the mechanism of action of pregabalin has not been fully elucidated, research with compounds structurally related to […]
AVASTIN (bevacizumab) – a vascular endothelial growth factor-specific angiogenesis inhibitor commonly used to treat certain cancers. Bevacizumab binds VEGF and prevents the interaction of VEGF to its receptors (Flt-1 and KDR) on the surface of endothelial cells. The interaction of VEGF with its receptors leads to endothelial cell proliferation and new blood vessel formation in […]
LANTUS (insulin glargine recombinant) – a acting human insulin analog indicated to improve glycemic control in adults and children with type 1 diabetes mellitus and in adults with type 2 diabetes mellitus. The primary activity of insulin, including insulin glargine, is regulation of glucose metabolism. Insulin and its analogs lower blood glucose by stimulating peripheral […]
JANUVIA (sitagliptin) – a dipeptidyl peptidase-4 (DPP-4) inhibitor indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. DPP-4 inhibitors, are believed to exert their actions in patients with type 2 diabetes by slowing the inactivation of incretin hormones. By increasing and prolonging active incretin levels, […]