CELEBREX (celecoxib) – a nonsteroidal anti-inflammatory drug (NSAID) commonly used to treat various arthritic conditions and other types or pain. The mechanism of action of CELEBREX is believed to be due to inhibition of prostaglandin synthesis, primarily via inhibition of cyclooxygenase-2 (COX-2), and at therapeutic concentrations in humans, CELEBREX does not inhibit the cyclooxygenase-1 (COX-1) […]
REMICADE (infliximab) – a biologic anti-inflammatory agent that binds specifically to TNF-alpha and blocks its interaction with the p75 cell surface TNF receptor. TNF is a naturally occurring cytokine that is involved in normal inflammatory and immune responses. Elevated levels of TNF are found in the synovial fluid of patients with RA, JIA, PsA, and […]
ENBREL (etanercept) – a biologic anti-inflammatory agent that binds specifically to TNF-alpha and blocks its interaction with the p75 cell surface TNF receptor. TNF is a naturally occurring cytokine that is involved in normal inflammatory and immune responses. Elevated levels of TNF are found in the synovial fluid of patients with RA, JIA, PsA, and […]
HUMIRA (adalimumab) – a monoclonal antibody that binds specifically to TNF-alpha and blocks its interaction with the p55 and p75 cell surface TNF receptors. Adalimumab also lyses surface TNF expressing cells in vitro in the presence of complement. TNF is a naturally occurring cytokine that is involved in normal inflammatory and immune responses. Elevated levels […]