ADVAIR (fluticasone/salmererol) – an inhaled combination product containing a corticosteroid (fluticasone), and a long-acting beta-2 adrenergic agonist (salmeterol) commonly used to treat asthma and chronic obstructive pulmonary disease (COPD). The mechanism of action for fluticasone/salmererol is related to the two active ingredients. Fluticasone is a potent corticosteroid that posses anti-inflammatory properties, relieving inflammation in the […]
HUMIRA (adalimumab) – a monoclonal antibody that binds specifically to TNF-alpha and blocks its interaction with the p55 and p75 cell surface TNF receptors. Adalimumab also lyses surface TNF expressing cells in vitro in the presence of complement. TNF is a naturally occurring cytokine that is involved in normal inflammatory and immune responses. Elevated levels […]
CYMBALTA (duloxetine) – a serotonin reuptake inhibitor commonly used to treat depression, anxiety and certain pain disorders. The mechanism of action for duloxetine is unknown. However, it is believed that duloxetine’s actions are related to its ability to increase serotonergic and noradrenergic activity in the central nervous system. FDA approved uses: 1. Treatment of […]
CRESTOR (rosuvastatin) – is an antilipidemic drug commonly used to treat excess lipids (primarily cholesterol and triglycerides) in patients with these disorders. Rosuvastatin is an inhibitor of HMG-CoA reductase (statin) indicated as an adjunct therapy to diet to reduce the risk of MI, stroke and arterial revascularization in patients without clinically evident CHD, but with […]