TOPROL-XL (metoprolol succinate) – a beta-1-selective adrenoreceptor blocking agent commonly used to treat hypertension, angina, and heart failure. The mechanism of the antihypertensive effects of beta-blocking agents has not been elucidated. However, several possible mechanisms have been proposed: (1) competitive antagonism of catecholamines at peripheral (especially cardiac) adrenergic neuron sites, leading to decreased cardiac output; […]
On February 25, 2013 the U.S. Food and Drug Administration announced approval of Stivarga (regorafenib) for a new indication, to treat patients with advanced gastrointestinal stromal tumors that cannot be surgically removed and no longer respond to other FDA-Approved treatments for this condition. GIST is a tumor in which cancerous cells form in the tissues […]
We’ve all heard of the Mediterranean diet, which is a diet rich in olive oil, nuts, beans, fish, fruits, vegetables, and even the occasional glass of wine with dinner. Now, a new study published on the website of the New England Journal of Medicine announced findings that show a definite clinical benefit to the Mediterranean […]
On February 22, 2012 the U.S. Food and Drug Administration approved Kadcyla (ado-trastuzumab emtansine), a new therapy for patients with HER2-positive, late-stage (metastatic) breast cancer. HER2 is a protein involved in normal cell growth. It is found in increased amounts on some types of cancer cells (HER2-positive), including some breast cancers. In these HER2-positive breast […]