NOVOLOG (insulin aspart recombinant) – an insulin analog indicated to improve glycemic control in adults and children with diabetes mellitus. The primary activity of insulin, including insulin aspart, is regulation of glucose metabolism. Insulin and its analogs blood glucose by facilitating the cellular uptake of glucose and simultaneously inhibiting the output of glucose from the […]
LEVEMIR (insulin detemir recombinant) – a long acting human insulin analog indicated to improve glycemic control in adults and children with diabetes mellitus. The primary activity of insulin, including insulin detemir, is regulation of glucose metabolism. Insulins, including insulin detemir, exert their specific action through binding to insulin receptors. Receptor-bound insulin lowers blood glucose by […]
VIAGRA (sildenafil) – a phosphidiesterase-5 (PDE-5) inhibitor drug commonly used to treat erectile dysfunction in men. The physiologic mechanism of erection of the penis involves release of nitric oxide (NO) in the corpus cavernosum during sexual stimulation. NO then activates the enzyme guanylate cyclase, which results in increased levels of cyclic guanosine monophosphate (cGMP), producing […]
ALIMTA (pemetrexed disodium) – a folate analog metabolic inhibitor commonly used to treat certain types of lung cancer and mesothelioma. Alimta exerts its action by disrupting folate-dependent metabolic processes essential for cell replication. FDA approved uses: Alimta is indicated for Locally Advanced or Metastatic Nonsquamous Non-Small Cell Lung Cancer -Initial treatment in combination with cisplatin; […]