VIAGRA (sildenafil) – a phosphidiesterase-5 (PDE-5) inhibitor drug commonly used to treat erectile dysfunction in men. The physiologic mechanism of erection of the penis involves release of nitric oxide (NO) in the corpus cavernosum during sexual stimulation. NO then activates the enzyme guanylate cyclase, which results in increased levels of cyclic guanosine monophosphate (cGMP), producing […]
ALIMTA (pemetrexed disodium) – a folate analog metabolic inhibitor commonly used to treat certain types of lung cancer and mesothelioma. Alimta exerts its action by disrupting folate-dependent metabolic processes essential for cell replication. FDA approved uses: Alimta is indicated for Locally Advanced or Metastatic Nonsquamous Non-Small Cell Lung Cancer -Initial treatment in combination with cisplatin; […]
SEROQUEL (quetiapine fumarate) – an atypical antipsychotic agent commonly used to treat schizophrenia and certain types of bipolar disorder. Though the exact mechanism of action of quetiapine is unknown, it is thought that Seroquel exerts its effects in schizophrenia and bipolar depression and mania through a combination of dopamine type 2 (D2) and serotonin type […]
INCIVEK (telaprevir) – a hepatitis C virus (HCV) NS3/4A protease inhibitor commonly used, in combination with peginterferon alfa and ribavirin, to treat type hepatitis C. Telaprevir exerts its effects by acting directly against the hepatitis C virus. FDA approved uses: Incivek is indicated, in combination with peginterferon alfa and ribavirin, for the treatment of genotype […]