Lovaza (omega-3-acid ethyl esters)
LOVAZA (omega-3-acid ethyl esters) – a combination of ethyl esters of omega 3 fatty acids, principally EPA and DHA commonly used to elevated triglyceride (TG) levels. The mechanism of action of Lovaza is not completely understood. Potential mechanisms of action include inhibition of acyl-CoA:1,2-diacylglycerol acyltransferase, increased mitochondrial and peroxisomal beta-oxidation in the liver, decreased lipogenesis in the liver, and increased plasma lipoprotein lipase activity.
FDA approved uses: Lovaza is indicated as an adjunct to diet and exercise to reduce triglyceride (TG) levels in adult patients with severe ( >500 mg/dL) hypertriglyceridemia. Limitations of Use – The effect of Lovaza on cardiovascular mortality and morbidity in patients with elevated triglycerides has not been determined.
Available dosage forms: Capsules – 1-gram transparent soft-gelatin.
Usual dosage: The daily dose of Lovaza is 4 grams per day taken as a single 4-gram dose (4 capsules) or as two 2-gram doses (2 capsules given twice daily).
Contraindications: Patients with known hypersensitivity (anaphylactic reactions) to Lovaza or to any excipients used in the formulation.
Special warnings: In patients with hepatic impairment, monitor ALT and AST levels periodically during therapy. Lovaza may increase levels of LDL. Monitor LDL levels periodically during therapy; Use with caution in patients with known hypersensitivity to fish and/or shellfish; There is a possible association between Lovaza and more frequent recurrences of symptomatic atrial fibrillation or flutter in patients with paroxysmal or persistent atrial fibrillation, particularly within the first months of initiating therapy.
Adverse reactions (side effects) of these medications: The most common side effects of Lovaza include eructation, dyspepsia, and taste perversion. Other adverse events reported include Constipation, gastrointestinal disorder, vomiting, increased ALT, increased AST, pruritus and rash.
Common drug interactions: Some studies with omega-3-acids in patients also taking anticoagulants demonstrated prolongation of bleeding time. The prolongation of bleeding time reported in these studies has not exceeded normal limits and did not produce clinically significant bleeding episodes. Patients receiving treatment with Lovaza and an anticoagulant or other drug affecting coagulation should be monitored periodically (e.g., aspirin, NSAIDS, warfarin, coumarin).
Special instructions for patients: Take this medication exactly as directed by physician. Read the official Medication Guide before starting Lovaza and when you receive new refills. You should not take more than 4 capsule of Lovaza each day. Call your doctor right away if you have side effects that are bothersome to you.
Full prescribing information may be found at the manufacturer‘s official website Lovaza.com or at the U.S. Food and Drug Administration’s website at Lovaza Info at Drugs@FDA
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