Oxycontin (oxycodone extended release)

OXYCONTIN (oxycodone) – an opioid agonist product commonly used to treat moderate to severe pain in patients requiring continuous around the clock opioid analgesia.

FDA approved uses: Oxycontin is indicated for the management of moderate to severe pain when a continuous, around-the-clock opioid analgesic is needed for an extended period of time.

OxyContin is NOT for use: As an as-needed (prn) analgesic; For pain that is mild or not expected to persist for an extended period of time; For acute pain in the immediate postoperative period; For postoperative pain, unless the patient is already receiving chronic opioid therapy prior to surgery, or if the postoperative pain is expected to be moderate to severe and persist for an extended period of time. OxyContin 60 mg and 80 mg tablets are only for patients in whom tolerance to an opioid of comparable potency is established..

Available dosage forms: Tablets, Extended Release – 10, 15, 20, 30, 40, 60 and 80 mg.

Usual dosage: Individualize dosing based on patient’s prior analgesic treatment experience, and titrate as needed to provide adequate analgesia and minimize adverse reactions. Do not abruptly discontinue OxyContin in a physically dependent patient. Tablets must be swallowed intact and are not to be cut, broken, chewed, crushed, or dissolved (risk of potentially fatal dose).

Contraindications: Do not administer to patients with any of the following conditions: Significant respiratory depression; Acute or severe bronchial asthma; Known or suspected paralytic ileus; Hypersensitivity to oxycodone.

Adverse reactions (side effects) of these medications: The most common side effects of Oxycontin include constipation, nausea, somnolence, dizziness, vomiting, pruritus, headache, dry mouth, asthenia, and sweating. Other adverse reactions seen in clinical trials or post-marketing include: chills, fever, anorexia, abdominal pain, diarrhea, dyspepsia, gastritis, twitching, anxiety, confusion, dyspnea, rash, postural hypotension, tinnitus and abnormal vision.

Common drug interactions: A number of drugs have been reported to interact with Oxycontin. Concurrent administration of oxycontin and other central nervous system (CNS) depressants including sedatives or hypnotics, general anesthetics, phenothiazines, tranquilizers, and alcohol can increase the risk of respiratory depression, hypotension, profound sedation or coma. Oxycodone can enhance the actions of true skeletal muscle relaxants, producing a more profound degree of respiratory depression. Oxyconton has also been found to interact with drugs that drugs that affect the cytochrome P450 enzyme system (e.g. ketoconazole and quinidine), with mixed agonist/antagonist opioid analgesics, with diuretics, and anticholinergics.

Special instructions for patients: Take exactly as prescribed by physician. Do not change the dose you were prescribed. To not take if you have asthma, trouble breathing or lung problems. Do not take if you have a bowel blockage or narrowing of the stomach or intestines. Swallow whole. Do not cut, break, chew, crush, dissolve or inject Oxycontin.

Full prescribing information may be found at the manufacturer‘s official website PurduePharma.com or at the U.S. Food and Drug Administration’s website at Oxycontin Info at Drugs@FCDA

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